Sandra Romero Pinto
Department of Otolaryngology, Massachusetts Eye and Ear
Project Title: Recovery of cortical sound processing following peripheral and central rescue
The main focus of this project was to study recovery of hearing and cross-modal plasticity in a mouse model of cochlear gene therapy following congenital deafness. The fellow will train in small animal survival surgery and neurophysiological recordings from single neuron recordings in the auditory and visual cortex of awake mice. We will quantify the changes in sensory tuning in the auditory and visual modalities of individual neurons with respect to wild type mice, and correlate it with peripheral recordings (brainstem and cochlear responses) and the performance of behavioral tasks. The fellow will also collaborate in a second project in a mouse model with induced deafness which has undergone training with optogenetics neuromodulation. The recordings will be made with epifluorescence imaging techniques at the auditory cortex from awake head-restraint mice. The fellow will optimize the algorithm for decoding stimuli information through spatial patterns with these modalities.