Project Summary: Cortical projection neurons are integral to many of the most important capacities of neural circuitry, including sensation, motion, and higher-order cognition. These glutamatergic neurons cross extremely long distances -- up to 10,000s...
Project Summary: General anesthesia transformed the way we perform surgery and is essential for many diagnosis or therapeutic procedures. Yet, the spatiotemporal dynamics leading to a state of general anesthesia are still to be deciphered.
This project...Project Summary: Nicolas worked on using iEEG recordings in an animal model of epilepsy to predict occurrence of spontaneous seizures. Mesial temporal lobe epilepsy, which is the most common form of focal epilepsy in humans, is obtained in animals with...
Project Summary: Disruption of the corticospinal pathway following spinal cord injury or stroke is known to drastically debilitate skilled locomotion. This pathway is mainly involved in bridging and decoding sensory information to be translated for the...
Project Summary: Relay neurons in the lateral geniculate nucleus of the thalamus (dLGN) exhibit diverse and sharp visual tuning, suggesting functionally specific convergence of retinal ganglion cell (RGC) axons onto dLGN neurons. However, technical...
Project Summary: Epilepsy is one of the most common neurological chronic brain disorders, affecting nearly 50 million people globally. In the clinic, the most widely used evaluation for the diagnosis of epilepsy is the detection of interictal (between...
Project Summary: The main focus of this project was to study recovery of hearing and cross-modal plasticity in a mouse model of cochlear gene therapy following congenital deafness. The fellow will train in small animal survival surgery and...
Project Summary: Mr. Sperisen will be trained in an array of biochemical and biophysical techniques, and will then apply these techniques to determine whether specific forms of the Alzheimer's disease associated Abeta protein can be extracted from human...
Project Summary: The goal of the study is to measure the neural representation of sound frequency in mice while they are passively listening versus engaged in a behavioral discrimination task. We will use widefield epifluorescence imaging of a...
